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IK1 inhibitor PA-6

CAS No. 500715-03-7

IK1 inhibitor PA-6 ( —— )

Catalog No. M22001 CAS No. 500715-03-7

IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 In Stock
5MG 49 In Stock
10MG 95 In Stock
25MG 178 In Stock
50MG 302 In Stock
100MG 444 In Stock
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Biological Information

  • Product Name
    IK1 inhibitor PA-6
  • Note
    Research use only, not for human use.
  • Brief Description
    IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1.
  • Description
    IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse KIR2.x currents).
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    KIR2.x currents
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    500715-03-7
  • Formula Weight
    492.62
  • Molecular Formula
    C31H32N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120mg/ml (243.59 Mm; Need ultrasonic)
  • SMILES
    N=C(NC1=CC=C(OCCCCCOC2=CC=C(NC(=N)C3=CC=CC=C3)C=C2)C=C1)C1=CC=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590.2. Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44.
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